2017

M.E. Cannon, Q. Duan, Y. Wu, M. Zeynalzadeh, Z. Xu, A.J. Kangas, P. Soininen, M. Ala-Korpela, M. Civelek, A.J. Lusis, J. Kuusisto, F.S. Collins, M. Boehnke, H. Tang, M. Laakso, Y. Li, K.L. Mohlke. “Trans-ancestry Fine Mapping and Molecular Assays Identify Regulatory Variants at the ANGPTL8 HDL-C GWAS Locus.” G3 (Bethesda). 2017

R.C. Schugar, D.M. Shih, M. Warrier, R.N. Helsley, A. Burrows, D. Ferguson, A.L. Brown, A.D. Gromovsky, M. Heine, A. Chatterjee, L. Li, X.S. Li, Z. Wang, B. Willard, Y. Meng, H. Kim, N. Che, C. Pan, R.G. Lee, R.M. Crooke, M.J. Graham, R.E. Morton, C.D. Langefeld, S.K. Das, L.L. Rudel, N. Zein, A.J. McCullough, S. Dasarathy, W.H.W. Tang, B.O. Erokwu, C.A. Flask, M. Laakso, M. Civelek, S.V. Naga Prasad, J. Heeren, A.J. Lusis, S.L. Hazen, J.M. Brown. “The TMAO-Producing Enzyme Flavin-Containing Monooxygenase 3 Regulates Obesity and the Beiging of White Adipose Tissue.” Cell Rep. 2017; 19(12):2451-2461

D. Wu, R.T. Huang, R.B. Hamanaka, M. Krause, M.J. Oh, C.H. Kuo, R. Nigdelioglu, A.Y. Meliton, L. Witt, G. Dai, M Civelek, N.R. Prabhakar, Y. Fang, G.M. Mutlu. “HIF-1α is required for disturbed flow-induced metabolic reprogramming in human and porcine vascular endothelium.eLife. 2017;6:e25217

T. Kessler, J. Wobst, B. Wolf, J. Eckhold, B. Vilne, R. Hollstein, S. von Ameln, T.A. Dang, H.B. Sager, P. M Rumpf, R. Aherrahrou, A. Kastrati, J.L.M. Björkegren, J. Erdmann, A.J. Lusis, M. Civelek, F.J. Kaiser, H. Schunkert. “Functional Characterization of the GUCY1A3 Coronary Artery Disease Risk Locus.” Circulation. 2017;136(5):476-489

M. Civelek, Y. Wu, C. Pan, C.K. Raulerson, A. Ko, A. He, C. Tilford, N.K. Saleem, A. Stancakova, L.J. Scott, C. Fuchsberger, H.M. Stringham, A.U. Jackson, N. Narisu, P.S. Chines, K.S. Small, J. Kuusisto, B.W. Parks, P. Pajukanta, T. Kirchgessner, F.S. Collins, P.S. Gargalovic, M. Boehnke, M. Laakso, K.L. Mohlke, A.J. Lusis. “Genetic regulation of adipose gene expression and cardio-metabolic traits.” Am J. Hum. Genet. 2017; 100(3): 428-43

C.D. Rau, M. Civelek, C. Pan, A. J. Lusis. “A Suite of Tools for Biologists That Improve Accessibility and Visualization of Large Systems Genetics Datasets: Applications to the Hybrid Mouse Diversity Panel.Methods Mol Biol. 2017; 1488:153-188

 

2016

J. Dennis, V. Truong, D. Aïssi, A. Medina-Rivera, S. Blankenberg, M. Germain, M. Lemire, L. Antounians, M. Civelek, R. Schnabel, P. Wells, M.D. Wilson, P.E. Morange, D.A. Trégouët, F. Gagnon. “Single nucleotide polymorphisms in an intergenic chromosome 2q region associated with tissue factor pathway inhibitor plasma levels and venous thromboembolism.” J. Thromb Haemos. 2016; 14(10):1960-1970.

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V. Codoni, Y. Blum, M. Civelek, C. Proust, O. Franzén, J. L. Björkegren, W. Le Goff, F. Cambien, A. J. Lusis, D. A. Trégouët. “Preservation Analysis of Macrophage Gene Co-expression Between Human and Mouse Identifies PARK2 as a Genetically controlled Master Regulator of Oxydative Phosphorylation in Humans.” G3 (Bethesda). 2016; 6(10):3361-3371.

Y. Kojima, J. P. Volkmer, K. McKenna, M. Civelek, A. J. Lusis, C. L. Miller, D. Direnzo, V. Nanda, J. Ye, A. J. Connolly, E. E. Schadt, T. Quertermous, P. Betancur, L. Maegdefessel, L. P. Matic, U. Hedin, I. L. Weissman, N. J. Leeper. “CD-47 blocking antibodies restore restore phagocytosis and prevent atherosclerosis.Nature. 2016; 536(7614):86-90.

H. A. Talukdar, H. Foroughi Asl, R. K. Jain, R. Ermel, A. Ruusalepp, O. Franzén, B. A. Kidd, B. Readhead, C. Giannarelli, J. C. Kovacic, T. Ivert, J. T. Dudley, M. Civelek, A. J. Lusis, E. E. Schadt, J. Skogsberg, T. Michoel, J. L. Björkegren. “Cross-tissue gene regulatory networks in coronary artery disease.Cell Syst. 2016; 2(3):196-208.

A. J. Lusis, M. M. Seldin, H. Allayee, B. J. Bennett, M. Civelek, R. C. Davis, E. Eskin, C. R. Farber, S. Hui, M. Mehrabian, F. Norheim, C. Pan, B. Parks, C. D. Rau, D. J. Smith, T. Vallim, Y. Wang, J. Wang. “The Hybrid Mouse Diversity Panel: a resource for systems genetics analyses of metabolic and cardiovascular traits.J. Lipid Res. 2016; 57(6):925-42

A. Gusev, A. Ko, H. Shi, G. Bhatia, W. Chung, B. W. Penninx, R. Jansen, E.J. de Geus, D. I. Boomsma, F. A. Wright, P. F. Sullivan, E. Nikkola, M. Alvarez, M. Civelek, A. J. Lusis, T. Lehtimäki, E. Raitoharju, M. Kähönen, I. Seppälä, O. T. Raitakari, J. Kuusisto, M. Laakso, A. L. Price, P. Pajukanta, B. Pasaniuc. “Integrative approaches for large scale transcriptome-wide association studies.Nat. Genet. 2016; 48(3):245-52

 

2015

B. J. Bennett, R. Davis, M. Civelek, L. Orozco, J. Wu, H. Qi, C. Pan, R. Packard, E. Eskin, T. Kirchgessner, S. Hazen, P. Gargalovic, A. J. Lusis.  “Genetic architecture of atherosclerosis: a systems genetics analysis of common inbred strains of mice.PLoS Genet. 2015; 11(12):e105711

T. S. Roman, A. F. Marvelle, M. P. Fogarty, S. Vadlamudi, A. J. Gonzalez, M. L. Buchkovich, J. R. Huyghe, C. Fuchsberger, A. U. Jackson, Y. Wu, M. Civelek, A. J. Lusis, K. J. Gaulton, P. Sethupathy, A. J. Kangas, P. Soininen, M. Ala-Korpela, J. Kuusisto, F. S. Collins, M. Laakso, M. Boehnke, K. L. Mohlke. Multiple hepatic regulatory variants at the GALNT2 GWAS locus associated with high-density lipoprotein cholesterol.Am. J. Hum. Genet. 2015; 97(6):801-15

A. Briot, M. Civelek, A. Seki, K. Hoi, H. Yu, G. A. Fishbein, L. Vakili, M. Fishbein, A. J. Lusis, M. Navab, J. A. Berliner, M. L. Iruela-Arispe. “Endothelial NOTCH1 is repressed by circulating lipids and antagonizes inflammation during atherosclerosis.J. Exp. Med. 2015; 212(12):2147-63

I. Brænne*, M. Civelek*, B. Vilne*, A. Di Narzo, A. D. Johnson, Y. Zhao, B. Reiz, V. Codoni, T. R. Webb, H. Foroughi-Asl, S. E. Hamby,  L. Zeng, D. A. Trégouët, K. Hao, E. J. Topol, E. E. Schadt, X. Yang, N. J. Samani, J. L. Björkegren, J. Erdmann, H. Schunkert, A. J. Lusis. Prediction of causal candidate genes in coronary artery disease loci. Arterioscler. Thromb. Vasc. Biol. 2015; 35(10):2207-17 *Equal contribution

R. E. Soccio, E. R. Chen, S. R. Rajapurkar, P. Safabakhsh, J. M. Marinis, J. R. Dispirito, M. J. Emmett, E. R. Briggs, B. Fang, L. J. Everett, H. W. Lim, K. J. Won, D. J. Steger, Y. Wu, M. Civelek, B. F. Voight, M. A. Lazar. Genetic variation determines PPARγ function and anti-diabetic drug response in vivo.Cell. 2015; 162(1):33-44

Y. Wu, R. T. Huang,  C. H. Kuo, S. Kumar, C. W. Kim, Y. C. Lin, Y. J. Chen, A. Birukova, K. G. Birukov, N. O. Dulin, M. Civelek, A. J. Lusis, X. Loyer, A. Tedgui, G. Dai, H. Jo, Y. Fang. Mechanosensitive PPAP2B regulates endothelial responses to atherorelevant hemodynamic forces Circ. Res. 2015; 117(4):e41-53

R. D. Kenagy*, M. Civelek*, S. Kikuchi, L. Chen, M. Sobel, A. J. Lusis, A. W. Clowes. SCARA5 and Suprabasin are hub genes of co-expression network modules associated with peripheral vein graft patency.J. Vasc. Surg. 2015; *Equal contribution

M. Germain, D. I. Chasman, H. deHaan, W. Tang, S. Lindström, L. Weng, M. de Andrade, M. de Visser, K. L. Wiggins, P. Suchon, N. Saut, D. Smadja, G. Legal, A. Di Narzo, K. Hao, C. P. Nelson, A. Rocanin-Arjo, L. Folkersen, R. Monajemi, L. M. Rose, J. A. Brody, E. Slagboom, D. Aissi, F. Gagnon, J. F. Deleuze, P. Deloukas, C. Tzourio, J. Dartigues, C. Berr, K. D. Taylor, M. Civelek, P. Eriksson, Cardiogenics Consortium, B. M. Psaty, J. Houwing-Duitermaat, A. H. Goodall, F. Cambien, N. J. Samani, P. Kraft, P. Amouyel, S. Basu, P. M. Ridker, F. R. Rosendaal, C. Kabrhel, A. R. Folsom, J. Heit, P. Reitsma, D. Trégouët, N. L. Smith, P. Morange. “Meta-analysis of 65,734 individuals identifies two new susceptibility loci for venous thrombosisAm J Human Genet.2015; 96(4):532-42.

J. H. Bahn, J. Ahn, X. Lin, J. H. Lee, Q. Zhang, M. Civelek and X. Xiao. “ADAR1 binds to non-Alu regions and regulates multiple RNA processing pathways.Nat. Commun. 2015; 6:6355.

M. Germain, M. G. Pezzolesi, N. Sandholm, A. J. McKnight, K. Susztak, M. Lajer, C. Forsblom, M. Marre, H. H. Parving, P. Rossing, I. Toppila, J. Skupien, R. Roussel, Y. Ko, N. Ledo, L. Folkerssen, M. Civelek, P. A. Maxwell, D. A. Tregouet, P. H. Groop, L. Tarnow and S. Hadjadj. “SORBS1 gene, a new candidate for diabetic nephropathy: results from a multi-stage genome wide association study in patients with Type 1 diabetes.Diabetologia. 2015; 58(3): 543-48

M. C. Romay, N. Che, S. Becker, D. Pouldar, R. Hagopian, X. Xiao, A. J. Lusis, J. B. Berliner and M. Civelek. “Regulation of NF-κB signaling by oxidized glycerophospholipid and IL-1β induced miRs-21-3p and -27a-5p in human aortic endothelial cells.J. Lipid Res. 2015; 56(1):38-50.

 

2014

M. Civelek and A. J. Lusis. “From hairballs to an understanding of transendothelial migration of monocytes in atherosclerosis.Arterioscler. Thromb. Vasc. Biol. 2014; 34:1809-1810.

V-P. Mäkinen, M. Civelek, Q-Y. Meng, B. Zhang, J. Zhu, C. Levian, S. Ghosh, J. Vivar, M. Nikpay, A. F. R. Stewart, C. P. Nelson, C. Willenborg, A. Segre, J. Erdmann, S. Blakenberg, C. O’Donnell, U. Thorsteinsdóttir, W. März, R. Laaksonen, S. E. Epstein, S. Kathiresan, S. H. Shah, S. L. Hazen, M. P. Reilly, CARDIoGRAM consortium, A. J. Lusis, N. J. Samani, H. Schunkert, T. Quertermous, R. McPherson, X. Yang and T. Assimes. “Integrative genomics reveals novel molecular pathways and gene networks for coronary artery disease.PloS Genet. 2014; 10(7): e1004502.

I. Iatan, H. Choi, I. Ruel, M. V. Reddy, H. Kil, J. Lee, M. A. Odeh, Z. Salah, M. Abu-Remaileh, D. Weissglas-Volkov, E. Nikkola, M. Civelek, Z. Awan, C. Croce, R. Aqeilan, P. Pajukanta, M. Aldaz and J. Genest. “The WWOX Gene Modulates HDL and Lipid Metabolism.Circ. Cardiovasc. Genet. 2014; 7(4):491-504.

M. Civelek and A. J. Lusis. “Systems genetics approaches to study complex traits.Nat Rev Gen. 2014; 15(1):34-48.

 

2013

A. Erbilgin*, M. Civelek*, C. E. Romanoski, C. Pan, R. Hagopian, J. A. Berliner and A. J. Lusis. “Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. J. Lipid Res. 2013; 54(7):1894-905. *Equal contribution.

P. F. Davies, M. Civelek, Y. Fang and I. Fleming. “The atherosusceptible endothelium: endothelial phenotypes in complex haemodynamic shear stress regions in vivo.” Cardiovasc. Res. 2013; 99(2):315-27.

M. Civelek, R. Hagopian, C. Pan, N. Che, W. P. Yang, P. S. Kayne, N. K. Saleem, H. Cederberg, J. Kuusisto, P. S. Gargalovic, T. G. Kirchgessner, M. Laakso and A. J. Lusis. “Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits.Hum. Mol. Genet. 2013; 22(15):3023-37.

Y. Mahendran, J. Vangipurapu, H. Cederberg, A. Stancáková, J. Pihlajamäki, P. Soininen, A. J. Kangas, J. Paananen, M. Civelek, N. K. Saleem, P. Pajukanta, A. J. Lusis, L. L. Bonnycastle, M. A. Morken, F. S. Collins, K. L. Mohlke, M. Boehnke, M. Ala-Korpela, J. Kuusisto and M. Laakso. “Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men.Diabetes. 2013; 62(10):3618-26.

T. Q. de Aguiar Vallim, E. J. Tarling, T. Kim, M. Civelek, A. Baldán, C. Esau and P. A. Edwards. “MicroRNA-144 regulates hepatic ATP binding cassette transporter A1 and plasma high-density lipoprotein after activation of the nuclear receptor farnesoid X receptor.Circ. Res. 2013; 112(12):1602-12.

B. W. Parks, E. Nam, E. Org, E. Kostem, F. Norheim, S. T. Hui, C. Pan, M. Civelek, C. D. Rau, B. J. Bennett, M. Mehrabian, L. K. Ursell, A. He, L. W. Castellani, B. Zinker, M. Kirby, T. A. Drake, C. A. Drevon, R. Knight, P. Gargalovic, T. G. Kirchgessner, E. Eskin and A. J. Lusis. “Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice.Cell Metab. 2013; 17(1):141-52.

 

 

2012

B. E. Haas, S. Horvath, K. H. Pietiläinen, R. M. Cantor, E. Nikkola, D. Weissglas-Volkov, A. Rissanen, M. Civelek, I. Cruz-Bautista, L. Riba, J. Kuusisto, J. Kaprio, T. Tusie-Luna, M. Laakso, C. A. Aguilar-Salinas and P. Pajukanta. “Adipose co-expression networks across Finns and Mexicans identify novel triglyceride-associated genes.BMC Med. Genomics. 2012; 5:61.

J. B. Kim, A. Deluna, I. N. Mungrue, C. Vu, D. Pouldar, M. Civelek, L. Orozco, J. Wu, X. Wang, S. Charugundla, L. W. Castellani, M. Rusek, H. Jakubowski and A. J. Lusis. “Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice.Circulation. 2012; 126(15):1896-906.

A. Ghazalpour, C. D. Rau, C. R. Farber, B. J. Bennett, L. D. Orozco, A. van Nas, C. Pan, H. Allayee, S. W. Beaven, M. Civelek, R. C. Davis, T. A. Drake, R. A. Friedman, N. Furlotte, S. T. Hui, J. D. Jentsch, E. Kostem, H. M. Kang, E. Y. Kang, J. W. Joo, V. A. Korshunov, R. E. Laughlin, L. J. Martin, J. D. Ohmen, B. W. Parks, M. Pellegrini, K. Reue, D. J. Smith, S. Tetradis, J. Wang, Y. Wang, J. N. Weiss, T. Kirchgessner, P. S. Gargalovic, E. Eskin, A. J. Lusis and R. C. LeBoeuf. “Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits.Mamm. Genome. 2012; 23(9-10):680-92.

A. Stancáková, M. Civelek, N. K. Saleem, P. Soininen, A. J. Kangas, H. Cederberg, J. Paananen, J. Pihlajamäki, L. L. Bonnycastle, M. A. Morken, M. Boehnke, P. Pajukanta, A. J. Lusis, F. S. Collins, J. Kuusisto, M. Ala-Korpela and M. Laakso. “Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men.Diabetes. 2012; 61(7):1895-902.

 

 

2011

C. E. Romanoski, N. Che, F. Yin, N. Mai, D. Pouldar, M. Civelek, C. Pan, S. Lee, L. Vakili, W. P. Yang, P. Kayne, I. N. Mungrue, J. A. Araujo, J. A. Berliner and A. J. Lusis. “Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1.Circ Res. 2011; 109(5):e27-41.

M. Civelek and A. J. Lusis. “Conducting the metabolic syndrome orchestra.Nat. Genet. 2011; 43(6):506-8.

M. Civelek, E. Manduchi, R. J. Riley, C. J. Stoeckert Jr and P. F. Davies. “Coronary artery endothelial transcriptome in vivo: identification of endoplasmic reticulum stress and enhanced reactive oxygen species by gene connectivity network analysis.Circ. Cardiovasc. Genet. 2011; 4(3):243-52.

M. Civelek, E. Manduchi, G. R. Grant, C. J. Stoeckert Jr and P. F. Davies. “Discovery approaches to UPR in athero-susceptible endothelium in vivo.Methods Enzymol. 2011; 489:109-26.

P. F. Davies and M. Civelek. “Endoplasmic reticulum stress, redox, and a proinflammatory environment in athero-susceptible endothelium in vivo at sites of complex hemodynamic shear stress.Antioxid. Redox Signal. 2011; 15(5):1427-32.

 

 

2010

Y. Fang, C. Shi, E. Manduchi, M. Civelek M and P. F. Davies. “MicroRNA-10a regulation of proinflammatory phenotype in athero-susceptible endothelium in vivo and in vitro.Proc. Natl. Acad. Sci. USA. 2010; 107(30):13450-5.

P. F. Davies, M. Civelek, Y. Fang, M. A. Guerraty and A. G. Passerini. “Endothelial heterogeneity associated with regional athero-susceptibility and adaptation to disturbed blood flow in vivo.Semin. Thromb. Hemost. 2010; 36(3):265-75.

M. Civelek, G. R. Grant, C. R. Irolla, C. Shi, R. J. Riley, O. A. Chiesa, C. J. Stoeckert Jr, J. W. Karanian, W. F. Pritchard and P. F. Davies. “Prelesional arterial endothelial phenotypes in hypercholesterolemia: universal ABCA1 upregulation contrasts with region-specific gene expression in vivo.Am. J. Physiol. Heart Circ. Physiol. 2010; 298(1):H163-70.

 

 

2009

M. Civelek, E. Manduchi, R. J. Riley, C. J. Stoeckert Jr and P. F. Davies. “Chronic endoplasmic reticulum stress activates unfolded protein response in arterial endothelium in regions of susceptibility to atherosclerosis.Circ. Res. 2009; 105(5):453-61.

 

 

2003

J. M. Tarbell, M. Civelek and J. S. Garanich. “Fluid Shear Stress Control of Vascular Smooth Muscle Cell.” Chapter in Molecular Basis for Microcirculatory Disorders. Editors: G. W. Schmid-Schönbein and D. N. Granger, Springer, 2003.

 

 

2002

M. Civelek, K. Ainslie, J. S. Garanich and J. M. Tarbell. “Smooth muscle cells contract in response to fluid flow via a Ca2+-independent signaling mechanism.J. Appl. Physiol. 2002; 93(6):1907-17.

R. Sharma, C. E. Yellowley, M. Civelek, K. Ainslie, L. Hodgson, J. M. Tarbell and H. J. Donahue. “Intracellular changes in rat aortic smooth muscle cells in response to fluid flow.Ann. Biomed. Eng. 2002; 30(3):371-8.